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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5
All Species:
57.27
Human Site:
S47
Identified Species:
90
UniProt:
Q00535
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00535
NP_004926.1
292
33304
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Chimpanzee
Pan troglodytes
XP_001149427
306
35062
T47
E
M
E
G
V
P
S
T
A
I
R
E
I
S
L
Rhesus Macaque
Macaca mulatta
XP_001102502
306
34957
T47
E
M
E
G
V
P
S
T
A
I
R
E
I
S
L
Dog
Lupus familis
XP_532760
331
37322
S86
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Cat
Felis silvestris
Mouse
Mus musculus
P49615
292
33270
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Rat
Rattus norvegicus
Q03114
292
33236
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001129258
292
33321
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Frog
Xenopus laevis
P51166
292
33320
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Zebra Danio
Brachydanio rerio
NP_571794
292
33381
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Honey Bee
Apis mellifera
XP_391878
299
34094
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
Nematode Worm
Caenorhab. elegans
NP_499783
292
33044
S47
D
D
E
G
V
P
S
S
A
L
R
E
I
C
I
Sea Urchin
Strong. purpuratus
XP_001200386
295
33676
V56
D
D
D
E
V
I
T
V
V
R
K
I
V
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T47
E
D
E
G
V
P
S
T
A
I
R
E
I
S
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
T47
E
D
E
G
V
P
S
T
A
I
R
E
I
S
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.1
58.8
86.7
N.A.
99.6
99.3
N.A.
N.A.
97.2
96.9
96.5
N.A.
77.5
81.9
73.6
67.1
Protein Similarity:
100
75.1
75.1
87.9
N.A.
100
99.6
N.A.
N.A.
98.9
98.9
98.9
N.A.
86.7
89.3
86.9
78.9
P-Site Identity:
100
66.6
66.6
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
93.3
20
P-Site Similarity:
100
86.6
86.6
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
100
46.6
Percent
Protein Identity:
N.A.
57.8
N.A.
56.4
N.A.
N.A.
Protein Similarity:
N.A.
76.8
N.A.
75.5
N.A.
N.A.
P-Site Identity:
N.A.
73.3
N.A.
73.3
N.A.
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
93.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
94
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% C
% Asp:
74
87
7
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
27
0
94
7
0
0
0
0
0
0
0
94
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
94
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
27
0
7
94
0
7
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
67
0
0
0
0
87
% L
% Met:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
94
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
7
94
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
94
67
0
0
0
0
0
27
0
% S
% Thr:
0
0
0
0
0
0
7
27
0
0
0
0
0
7
0
% T
% Val:
0
0
0
0
100
0
0
7
7
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _